Tocris Bioscience HIP-B
Potent, non-competitive EAAT inhibitor
Manufacturer: Tocris Bioscience 2218/10
DescriptionPotent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 µM) rather than [3H]L-glutamate uptake (IC50 = 16.9 µM). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC50 values are 35 and 45 µM respectively).
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