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HIST1H2BA Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549020

Catalog No. PA549020

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization. Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Specifications

Specifications

HIST1H2BA
Polyclonal
PBS with 0.09% sodium azide
Q96A08
Histone H2B type 1-A, Histone H2B, testis, TSH2B1, Testis-specific histone H2B, HIST1H2BA, TSH2B
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
255626
Western Blot
Unconjugated
HIST1H2BA
Liquid
HIST1H2BA
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BA.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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