Invitrogen™ HIST1H2BH Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA549864

Catalog No. PA549864

Description

The antibody detects endogenous levels of total Histone H2B protein.

In eukaryotes, DNA is wrapped around histone octamers to form the basic unit of chromatin structure. The octamer is composed of histones H2A, H2B H3 and H4 and it associates with approximately 200 base pairs of DNA to form the nucleosome. The association of DNA with histones results in dense packing of chromatin, which restricts proteins involved in gene transcription from binding to DNA. Histone H1 is required for the condensation of nucleosome chains into higher order structures. Phosporylation of Histone H1 is thought be involved in this process, although the exact nature of this role has yet to be elucidated. Evidence suggests that Histone H1 is a part of a general repressor mechanism for stable repression of transcription, but it can also activate transcription of specific genes.

Specifications

• Antigen: HIST1H2BH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: H2BC9
• Gene Alias: H2B histone family, member J; H2B.j; H2B/j; h2B-221; H2BFJ; Hist1h2bh; histone 1, H2bh; histone cluster 1, H2bh; histone H2B type 1-H; Histone H2B.j; Histone H2Bj
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8345
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q93079
• Gene Symbols: H2BC9
• Immunogen: Synthesized peptide derived from internal of human Histone H2B.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG