Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Histone H1.0 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 175101AP150UL
Description
PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.Specifications
Histone H1.0 | |
Polyclonal | |
Unconjugated | |
H1F0 | |
H1 histone family, member 0, H10, H1F0, H1FV, Histone H1, Histone H1(0), Histone H1.0 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
14958, 24437, 3005 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot | |
0.21 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P07305, P10922, P43278 | |
H1f0 | |
Histone H1.0 Fusion Protein Ag9982 | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Provide Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction