Histone H1.0 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 175101AP
DescriptionPTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P07305, P10922, P43278|
|H1 histone family, member 0, H10, H1F0, H1FV, Histone H1, Histone H1(0), Histone H1.0|
|14958, 24437, 3005|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|Histone H1.0 Fusion Protein Ag9982|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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