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Histone H3.3 Rabbit anti-Human, Non-human primate, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA524667

Catalog No. PIMA524667

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This antibody reacts to Histone H3.3, independent of post-translational modifications. No cross reactivity with Histone H3.1 or other histone proteins. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Histone H3 is one of the four core proteins of the nucleosome, and it is involved in transcription regulation, DNA repair, DNA replication and chromosomal stability. The N-terminal tail of Histone H3 undergoes many post-translational modifications, including phosphorylation, acetylation, multiple methylation, ubiquitination, and ADP-ribosylation to achieve its diverse functions. HistoneH3 is acetylated and deacetylated on N-terminal lysine residues. Acetylation removes the positive charge on the histone, decreasing the interaction with the negatively charged phosphate groups of DNA, and resulting in a more relaxed structure associated with greater levels of gene transcription. Acetylation of histone H3 at lysine 9 (H3K9Ac) is one of the most well-known epigenetic markers enriched in the promoter region of activated genes.


Histone H3.3
Recombinant Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH 7.2-7.4
H3 histone, family 3B (H3.3B); H3.3B; H3B; H3F3; H3F3B; H3L-like histone; histone H3.3
100 μg
-20° C, Avoid Freeze/Thaw Cycles
3020, 3021
ChIP assay, ELISA, Peptide Array, Western Blot
H3F3A, H3F3B
Peptide corresponding to human Histone H3.3.
Protein A
Human, Non-human primate
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