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Histone H3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549579

Catalog No. PA549579


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Description

Description

The antibody detects endogenous level of total Histone H3 protein.

Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called """"histone code"""". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases.
Specifications

Specifications

Histone H3
Polyclonal
Unconjugated
HIST1H3A
Liquid
H3c1, HIST1H3A, HIST1H3B, Hist2h3c2
Peptide sequence around aa.8∽12 (R-K-S-T-G) derived from Human Histone H3.1.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
ChIP assay, Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P68431, P68433, P84228
H3K9ac, Histone H3, Histone 1, H3a, Histone H3.1, histone H3/a, HIST1H3A, H3FA
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
310678, 314977, 319150, 360198, 679994, 8350, 8358, 97114
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