Histone H3R17me2aK18ac Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Active Motif 61614
DescriptionHistone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
|ChIP assay, Dot Blot, Western Blot|
|This antibody was raised against a synthetic peptide containing asymmetric dimethyl arginine 17 and acetyl lysine 18 of human Histone H3.|
|Antigen affinity chromatography|
|PBS with 30% glycerol and 0.035% sodium azide; pH 7.5|
|-20°C, Avoid Freeze/Thaw Cycles|
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