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GE Healthcare HiTrap™ MabSelect™ SuRe Prepacked Columns: PROMO

Use these columns in small-scale MAb purification in a continuous bioprocess. GE Healthcare Life Sciences™ HiTrap™ MabSelect™  SuRe (Superior Resistance) Prepacked Columns for fast purification of monoclonal antibodies (Mabs) from large sample volumes

Specifications

For Use With (Application) For fast purification of monoclonal antibodies from large sample volumes, affinity purification
Storage Requirements 4° to 30°C
Binding Capacity ≈35mg Human lgG/mL at 2.4 min. residence time
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Products 2
Catalog Number Mfr. No. Bed Volume Flow Rate Diameter (English) Inner Price Quantity & Availability  
Catalog Number Mfr. No. Bed Volume Flow Rate Diameter (English) Inner Price Quantity & Availability  
45-000-512LR View Documents GE Healthcare
29049104PM
1mL <4mL/min. 0.27 in. This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
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45-000-010LR View Documents GE Healthcare
11003495PM
5mL <20mL/min. 0.62 in. This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
View substitute products »
Description

Description

Prepacked HiTrap columns for process development, screening of purification conditions, and small-scale purification of Mabs. MabSelect media are suited for the high flowrates and pressures required when scaling up.

  • Oriented coupling of recombinant Protein A ligand to the agarose matrix via an engineered C-terminal cysteine increases IgG binding capacity over other protein A media
  • High capacity, low ligand leakage, and high-flow base matrix allow purification of Mabs at process scale
  • Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification
  • Designed for use with a syringe, a peristaltic pump, or a chromatography system

MabSelect

  • Allows at least five times higher flowrates than conventional cross-linked agarose of similar porosity
  • Recombinant Protein A ligand promotes specificity of binding to Fc region of IgG; permits one-step purification
MabSelect Xtra™
  • Same recombinant protein A ligand as MabSelect, but with a smaller particle size and greater porosity, for increased dynamic binding capacity
  • Allows binding from samples with high expression levels of the monoclonal antibody
  • Lowers overall production cost due to the possibility of processing concentrated feedstocks in fewer batches
MabSelect SuRe™ (Superior Resistance)
  • Akali-tolerant protein A-derived ligand allows the use of up to 0.5M NaOH for cleaning-in-place (CIP)
  • Permits significant cost savings and extension of cycles in regular production

Specifications

Specifications

For fast purification of monoclonal antibodies from large sample volumes, affinity purification
4° to 30°C
≈35mg Human lgG/mL at 2.4 min. residence time
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