HK2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA587552
Immunogen sequence: MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR; Positive Samples: 293T, K-562, HL-60; Cellular Location: Mitochondrion outer membraneIn vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predomit hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.
|Recombit fusion protein containing a sequence corresponding to amino acids 1-120 of human HK2|
|Human, Mouse, Rat|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|O08528, P27881, P52789|
|Antigen Affinity Chromatography|
|15277, 25059, 3099|
|-20° C, Avoid Freeze/Thaw Cycles|
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