HK2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587552

Catalog No. PIPA587552

Description

Immunogen sequence: MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLLEIS KRFRKEMEKG LGATTHPTAA VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLWVKVTDN GLQKVEMENQ IYAIPEDIMR; Positive Samples: 293T, K-562, HL-60; Cellular Location: Mitochondrion outer membrane

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase 2 is the predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Specifications

• Antigen: HK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hk2
• Gene Alias: AI642394, DKFZp686M1669, Hexokinase, hexokinase 2, hexokinase II, hexokinase type II, Hexokinase-2, hexokinase-2 muscle, hexokinase-2, muscle, Hexokinase-B, HK II, Hk2, HKII, HXK2, muscle form hexokinase, OTTHUMP00000202738
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15277, 25059, 3099
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.05 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
• Gene Accession No.: O08528, P27881, P52789
• Gene Symbols: Hk2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human Hexokinase II (NP_0001802)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov