Tocris HKI 357
Dual irreversible inhibitor of ErbB2 and EGFR
Manufacturer: Tocris 3580/50
DescriptionPotent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC50 values are 33 and 34nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa (Cat. No. 3000) in non-small-cell lung cancer cells.
- Chemical Name: (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
- Formula: C31H29ClFN5O3
- CAS Number: 848133-17-5
- Solubility: Soluble to 100mM in DMSO and to 25mM in ethanol
- Purity: >98
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