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HLA-DP Mouse anti-Human, Clone: SPM421, Abnova™

Mouse monoclonal antibody raised against native human HLA-DP.

Manufacturer:  Abnova Corporation MAB13076

Catalog No. 89-934-263


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Description

Description

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq]

Specifications

Specifications

HLA-DP
SPM421
Mouse monoclonal antibody raised against native human HLA-DP.
In 10mM PBS.
DPB1/HLA-DP1B
Mouse
IgG2b, kappa
100 ug
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Recognizes a non-polymorphic determinant of DP-MHC class II. MHC class II antigens are transmembrane glycoproteins of non-covalently linked alpha (33-35 kDa) and beta (27-30 kDa) chains. It reportedly reacts with B- & non-T, non-B cell lines but not with T- and myeloid cell lines and leukemias. Differential expression of MHC class II antigens on fetal and adult lymphocytes, malignant B cells appears to reflect the stage of cell differentiation which may be useful in the study of lymphoproliferative disorders.
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Liquid
HLA-DPB1
Human non-T/non-B-cell-type acute lymphoblastic leukemia REH6 cell line.
Protein A/G purification
RUO
Primary
3115
Human
SDS
Documents
Product Certifications
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