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HLA-DP Mouse anti-Human, Clone: SPM421, Abnova™
Mouse monoclonal antibody raised against native human HLA-DP.
Supplier: Abnova Corporation MAB13076
Description
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq]
Specifications
HLA-DP | |
Monoclonal | |
Unconjugated | |
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user. | |
DPB1/HLA-DP1B | |
Mouse | |
Protein A/G purification | |
RUO | |
3115 | |
Human | |
Liquid |
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed) | |
SPM421 | |
Mouse monoclonal antibody raised against native human HLA-DP. | |
In 10mM PBS. | |
HLA-DPB1 | |
Human non-T/non-B-cell-type acute lymphoblastic leukemia REH6 cell line. | |
100 μg | |
Primary | |
Recognizes a non-polymorphic determinant of DP-MHC class II. MHC class II antigens are transmembrane glycoproteins of non-covalently linked alpha (33-35 kDa) and beta (27-30 kDa) chains. It reportedly reacts with B- & non-T, non-B cell lines but not with T- and myeloid cell lines and leukemias. Differential expression of MHC class II antigens on fetal and adult lymphocytes, malignant B cells appears to reflect the stage of cell differentiation which may be useful in the study of lymphoproliferative disorders. | |
Store at -20 to -80°C. Aliquot to avoid repeated freezing and thawing. |
|
IgG2b κ |
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