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HLA-DR Mouse anti-Human, PE-Cyanine5.5, Clone: TU36, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHLDR18

Catalog No. 50-112-1482


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Description

Description

The R-phycoerythrin (PE)-Cy5.5™ tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

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Specifications

Specifications

HLA-DR
Monoclonal
PE-Cyanine5.5
HLA-DRB1
Liquid
HLA-DRB1
Human HLA-DR
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
TU36
PBS with 10% sucrose, BSA and 0.1% sodium azide
P04229
HLA-DRA1, MLRW, HLA class II histocompatibility antigen, DR alpha chain, MHC cell surface glycoprotein, MHC class II antigen DRA, histocompatibility antigen HLA-DR alpha
Mouse
IgG2b
0.5 mL
4° C, store in dark
Primary
3123
Documents
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