HLA-G Monoclonal Antibody (MEM-G/9), APC, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA119465

Catalog No. 01-676-200

Description

This antibody reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. Reactivity with HLA-G3 was also reported. It will not cross-react with mouse.

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

Specifications

• Antigen: HLA-G
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Gene: HLA-G
• Gene Alias: DADB-15K14.8, MHC-G
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3135
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: MEM-G/9
• Conjugate: APC
• Gene Accession No.: P17693
• Gene Symbols: HLA-G
• Immunogen: Recombit human HLA-G refolded with beta- 2 Microglobulin and peptide.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1