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HM13 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA560919

Catalog No. PIPA560919


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Description

Description

Immunogen sequence: PASFPNRQYQ LLFTQGSGEN KEEIINYEFD TKDLVCLGLS SIVGVWYLLR KHWIANNLFG LAFSLNGVEL LHLNNVSTGC Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:12145199, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner (PubMed:25239945).
Specifications

Specifications

HM13
Polyclonal
Unconjugated
HM13
Liquid
HM13
Recombit protein corresponding to Human HM13
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry, Western Blot
0.05 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q8TCT9
Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
81502
Documents
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