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TCF2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549690

Catalog No. PA549690


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Description

Description

The antibody detects endogenous level of total HNF1B protein.

Hepatocyte Nuclear Factor 1- (HNF-1 , Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor ) is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1; depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.
Specifications

Specifications

TCF2
Polyclonal
Unconjugated
HNF1B
Liquid
HNF1B
Peptide sequence around aa.252∽256(R-Q-K-N-P) derived from Human HNF-1beta(TCF-2).
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P35680, P27889, P23899
FJHN, HNF2, LFB3, TCF2, HPC11
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
21410, 25640, 6928
Documents
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