Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
HOXD11 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 187341AP150UL
Description
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintece of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.Specifications
HOXD11 | |
Polyclonal | |
Unconjugated | |
HOXD11 | |
homeobox D11, Homeobox protein Hox 4F, Homeobox protein Hox D11, HOX4, HOX4F, HOXD11 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
102553842, 15431, 3237 | |
-20°C | |
Liquid |
Western Blot | |
0.29 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P23813, P31277 | |
Hoxd11 | |
Peptide | |
150 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Provide Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction