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HRK Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA5107146

Catalog No. PIPA5107146


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Description

Description

Sequence homology: Cow: 100%; Dog: 100%; Human: 100%; Mouse: 83%; Rabbit: 100%; Rat: 83%

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
Specifications

Specifications

HRK
Polyclonal
Unconjugated
HRK
Liquid
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8739
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
O00198
HRK
Synthetic peptide located within the following region: MCPCPLHRGR GPPAVCACSA GRLGLRSSAA QLTAARLKAL GDELHQRTMW
Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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