Invitrogen™ HSF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596200

Catalog No. PIPA596200

Description

Positive Samples: 293T, HepG2, SW620, BT-474; Cellular Location: Cytoplasm, Nucleus Immunogen sequence: LDEQRFAKEI LPKYFKHNNM ASFVRQLNMY GFRKVVHIDS GIVKQERDGP VEFQHPYFKQ GQDDLLENIK RKVSSSKPEE NKIRQEDLTK IISSAQKVQI KQETIESRLS ELKSENESLW KEVSELRAKH AQQQQVIRKI VQFIVTLVQN NQLVSLKRKR PLLLNTNGAQ KKNLFQH.

Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.

Specifications

• Antigen: HSF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HSF2
• Gene Alias: AI661205; heat shock factor 2; heat shock factor protein 2; Heat shock transcription factor 2; HSF 2; Hsf2; HSTF 2; HSTF2; MGC117376; MGC156196; MGC75048
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3298, 64441
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.46 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q03933
• Gene Symbols: HSF2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 39-215 of human HSF2 (Q03933).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov