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HSF2 Mouse anti-Human, Clone: OTI2A7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526871

Catalog No. PIMA526871


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Description

Description

Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.
Specifications

Specifications

HSF2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q03933
Heat shock factor protein 2; HSF 2; Heat shock transcription factor 2; HSTF 2; HSTF2
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3298
Immunohistochemistry (Paraffin), Western Blot
OTI2A7
Unconjugated
HSF2
Liquid
HSF2
Human recombit protein fragment corresponding to amino acids 74-324 of HSF2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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