HSF2 Mouse anti-Human, Clone: OTI3E1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526869
DescriptionProkaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Heat shock factor protein 2; HSF 2; Heat shock transcription factor 2; HSTF 2; HSTF2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 74-324 of HSF2 produced in E.coli|
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