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HSP70 Rat anti-Drosophila, Clone: 7FB, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA527627

Catalog No. PIMA527627


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Description

Description

HSP70 is a Heat shock protein (HSP) which are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs that include HSP70, there are HSP90 and HSP100. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. Further, HSP70 is encoded by an intronless gene and, in conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Specifications

Specifications

HSP70
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
Q9BIS2
HSP70Bb, Heat Shock Protein 70Bb, dHSP70, HSP70b, HSP70B, Dm-HSP70
Rat
IgG2B
100 μg
-20°C
Primary
48582
ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
7FB
Unconjugated
Hsp70Bb
Liquid
Hsp70Bb
Prepared from Drosophila tissue culture cells heat shocked at 36.5C for 3 hours, and isolated using SDS PAGE
Protein G
RUO
Antibody
Monoclonal
Drosophila
Documents
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