HSPA5 Mouse anti-Human, Rat, Clone:9E4-2A7-H6, Abnova™
Mouse monoclonal antibody raised against recombinant human HSPA5.
Manufacturer: Abnova Corporation MAB17662
DescriptionWhen Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as ′immunoglobulin heavy chain-binding protein′ (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM]
|heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)|
|In PBS, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|This antibody detects endogenous levels of HSPA5 and does not cross-react with related proteins.|
|Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot|
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.
|BIP, FLJ26106, GRP78, MIF2|
|Recombinant protein corresponding to a fragment at C-terminus of human HSPA5 from E. coli.|
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