BABAM1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA549611
Predicted to react with bovine, mouse and rat based on sequence homology.Component of the BRCA1-A complex, a complex that specifically recognizes ft.Lys-63 ft.-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ft.Lys-63 ft.-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ft.Lys-63 ft.-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ft.Lys-63 ft.-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.
|PBS with 0.09% sodium azide|
|BRISC and BRCA1-A complex member 1, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex, BABAM1, C19orf62, MERIT40, NBA1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|KLH conjugated synthetic peptide between 116-143 amino acids from the Central region of human HSPC142.|
|Ammonium sulfate precipitation|
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