CD11c Mouse anti-Human, Unlabeled, Clone: 3.9, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 565805
The 3.9 monoclonal antibody specifically binds to CD11c, which is also known as Integrin alpha X ( α X Integrin/ITGAX), or p150,95 Integrin alpha chain. CD11c is a ~150 kDa type I transmembrane glycoprotein. It is expressed on monocytes, macrophages, granulocytes, NK cells, dendritic cells, and subsets of B and T cells. It associates with CD18 (Integrin beta 2/ β 2 Integrin) to form the CD11c/CD18 complex, which is also known as p150,95 Integrin, or the Type 4 Complement Receptor (CR4). CD11c/CD18 binds fibrinogen and reportedly serves as a receptor for iC3b and ICAM-1/CD54. CD11c/CD18 functions as an adhesion molecule that mediates cellular binding to ligands expressed on stimulated epithelium and endothelium. The 3.9 monoclonal antibody crossreacts with Rhesus macaque leucocytes.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C|
|Flow Cytometry, Immunofluorescence|
|ITGAX; AlphaX Integrin; Axb2; Integrin alpha-X; CR4; SLEB6; p150,95 alpha|
|Human monocytes and synovial cells|
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