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Gibco™ Human 4-1BB Ligand (TNFSF9), Animal-Free Recombinant Protein, PeproTech®
E. coli Recombinant Protein
$249.00 - $3680.00
Specifications
| Accession Number | P41273 |
|---|---|
| For Use With (Application) | Functional Assay |
| Formulation | protein with no preservative |
| Gene ID (Entrez) | 8744 |
| Molecular Weight (g/mol) | 19.5 |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
AF31011100
|
Gibco™
AF31011100UG |
100 μg |
Each for $764.00
|
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AF310111MG
|
Gibco™
AF310111MG |
1 mg |
Each for $3,680.00
|
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|
AF3101120UG
|
Gibco™
AF3101120UG |
20 μg |
Each for $249.00
|
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|
AF31011500
|
Gibco™
AF31011500UG |
500 μg |
Each for $2,205.00
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Description
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.Specifications
| P41273 | |
| protein with no preservative | |
| 19.5 | |
| E. coli | |
| RUO | |
| 4 1 BB Ligand; 4 1 BBL; 41 BB Ligand; 4-1 BB ligand; 41 BBL; 4-1 BBL; 4-1 BB-L; AI848817; CD 137 Ligand; CD 137 L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1 BB-L; Ly63l; receptor 4-1 BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5 A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9 | |
| Human | |
| Recombinant | |
| Lyophilized |
| Functional Assay | |
| 8744 | |
| Human 4-1 BB Ligand (TNFSF9), Animal-Free | |
| -20°C | |
| <0.1 EU/μg | |
| TNFSF9 | |
| Unconjugated | |
| MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
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