Human ACVR1B (aa 32-126) His Tag, Recombinant Protein, Invitrogen™
CHO cells Recombinant Protein
Manufacturer: Thermo Scientific RP87815
DescriptionActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
|Control, ELISA, Western Blot|
|PBS with no preservative|
|6820432J04; activin A receptor type 1 B; activin A receptor type IB; activin A receptor, type 1 B; activin A receptor, type IB; activin A receptor, type II-like kinase 4; activin receptor type IB; Activin receptor type-1 B; activin receptor-like kinase 4; ACTRI; ActRIB; ActR-IB; ACVR1A; ACVR1B; ACVRLK2; Acvrlk4; ALK2; Alk4; ALK-4; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI|
|Human ACVR1B (aa 32-126) His Tag|
|0.1 EU/ µg cytokine|
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