Abnova™ Human ADAMTS4 Full-length ORF (AAH30812.1, 1 a.a. - 339 a.a.) Recombinant Protein with GST-tag at N-terminal

Used for AP, Array, ELISA, WB-Re

Supplier:  Abnova™ H00009507P01S

Catalog No. 89-932-599

Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq]

Sequence: MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQVRPQSAPQAMHCTILRSATT

Specifications

• Accession Number: AAH30812.1
• Formulation: 50mM Tris-HCI, 10mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Weight (g/mol): 62.4kDa
• Purification Method: Glutathione Sepharose 4 Fast Flow
• Quantity: 10μg
• Regulatory Status: RUO
• Common Name: ADAMTS4
• Species: Wheat Germ (in vitro)
• Protein Tag: GST Tag
• Form: Liquid

• For Use With (Application): Protein Array, ELISA, Western Blot
• Gene ID (Entrez): 9507
• Name: Human ADAMTS4 Full-length ORF (AAH30812.1, 1 a.a. - 339 a.a.) Recombinant Protein with GST-tag at N-terminal
• Quality Control Testing: 12.5% SDS-PAGE Stained with Coomassie Blue.
• Storage Requirements: Store at −80°C. Aliquot to avoid repeated freezing and thawing.
• Gene Alias: ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
• Gene Symbol: ADAMTS4
• Recombinant: Recombinant
• Expression System: wheat germ expression system