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Abnova™ Human ELA2 (30 a.a. - 247 a.a.) Partial native Protein from human blood

Used for Func, SDS-PAGE

Manufacturer:  Abnova™ P4923

Catalog No. 89-943-114


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Description

Description

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq]

Specifications

Specifications

0.2 mg/mL
Liquid
1991
ELA2 (Human) Native Protein
Saltprecipitation/Ion Exchange Chromatography/Gelfiltration
15% SDS-PAGE Stained with Coomassie Blue
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
GE|HLE|HNE|NE|PMN-E
ELA2
≥ 18mU/mg
None
Functional Study, Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
In 10mM acetate, pH 5.5
29kDa
Native protein purified from human blood
>95% by SDS-PAGE
25 ug
RUO
ELA2
Native protein purified from human blood
Human
Documents
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