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Abnova™ Human ERBB2 (NM_004448, 676 a.a. - end) Partial Recombinant Protein with GST-tag expressed in Sf9 cells

Used for Func, SDS-PAGE

Manufacturer:  Abnova™ P3860

Catalog No. 89-943-518


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Description

Description

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]

Specifications

Specifications

NM_004448
Liquid
2064
ERBB2 (Human) Recombinant Protein
>90% by densitometry
5 ug
RUO
ERBB2
Insect cell (Sf9) expression system
Insect
GST
Functional Study, Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Liquid
116kDa
Insect cell (Sf9) expression system
SDS-PAGE Stained with Coomassie Blue
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
CD340|HER-2|HER-2/neu|HER2|NEU|NGL|TKR1
ERBB2
The specific activity was determined to be 10nmol/min/mg as per Activity Assay Protocol.
Yes
Documents
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