Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Abnova™ Human ERBB2 (NP_004439.2, 1 a.a - 1255 a.a) Full length Recombinant Protein with His-Flag tag at C-terminal expressed in HEK293 cells

Used for SDS-PAGE

Manufacturer:  Abnova™ P6194

Catalog No. 89-943-523


Add to cart

Description

Description

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]

Specifications

Specifications

NP_004439.2
Liquid
2064
ERBB2 (Human) Recombinant Protein
Ni affinity column
SDS-PAGE (3ug/lane) stained with Coomassie Blue
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
<1.0 EU/μg as determined by the LAL method
ERBB2
Mammalian cell (HEK293) expression system
Yes
Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Liquid
73.5kDa
Mammalian cell (HEK293) expression system
>90% as determined by SEC-HPLC
100 ug
RUO
CD340|HER-2|HER-2/neu|HER2|NEU|NGL|TKR1
ERBB2
Human
His-Flag
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit