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Abnova™ Human ERBB3 (NP_001973.2, 1 a.a - 1342 a.a) Full length Recombinant Protein with His-Flag tag at C-terminal expressed in HEK293 cells

Used for SDS-PAGE

Manufacturer:  Abnova™ P6199

Catalog No. 89-943-530

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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq]



ERBB3 (Human) Recombinant Protein
Ni affinity column
SDS-PAGE (3ug/lane) stained with Coomassie Blue
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
<1.0 EU/μg as determined by the LAL method
Mammalian cell (HEK293) expression system
Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Mammalian cell (HEK293) expression system
>90% as determined by SEC-HPLC
25 ug
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