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Abnova™ Human FGFR4 (NM_002011, 391 a.a. - 802 a.a.) Partial Recombinant Protein with GST-His tag expressed in Sf9 cells

Used for Func, SDS-PAGE

Manufacturer:  Abnova™ P4693

Catalog No. 89-944-536


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Description

Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq]

Specifications

Specifications

NM_002011
Functional Study, Sodium Dodecyl Sulfate–Polyacrylamide Gel Electrophoresis
Liquid
75.726kDa
Insect cell (Sf9) expression system
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Store at -80°C. Aliquot to avoid repeated freezing and thawing
CD334|JTK2|MGC20292|TKF
FGFR4
47pmol/μg x min
Yes
0.245 ug/uL
Liquid
2264
FGFR4 (Human) Recombinant Protein
One-step affinity purification using GSH-agarose
100 ug
RUO
FGFR4
Insect cell (Sf9) expression system
Insect
GST-His
Documents
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