Invitrogen™ Human GATSL2 (aa 304-329) Control Fragment Recombinant Protein

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (88%), Rat (88%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63416 (PA5-63416. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Specifications

• Accession Number: A6NHX0
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Blocking Assay, Control
• Formulation: 1 M urea, PBS with no preservative; pH 7.4
• Gene ID (Entrez): 729438
• Name: Human GATSL2 (aa 304-329) Control Fragment
• Quantity: 100 μL
• Regulatory Status: RUO
• Gene Alias: CASTOR2; Cellular arginine sensor for mTORC1 protein 2; Cytosolic arginine sensor for mTORC1 subunit 2; GATL2; GATS protein like 2; GATS protein-like 1; GATS protein-like 2; GATSL1; GATSL2; GATS-like protein 1; GATS-like protein 2
• Common Name: GATSL2
• Gene Symbol: CASTOR2
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: FDHALVPEENINGVISALKVSQAEKH
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining