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eBioscience™ Human IL-29 (IFN-lambda1) Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of human IL-29.

$473.00 - $2985.00

Specifications

For Use With (Application) ELISA
Sample Size 50μL
Synonym IFNL1, Interleukin 29
Target Human
Conjugate Biotin
View More Specs

Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human IL-29
Biotin-Conjugate anti-human IL-29 monoclonal antibody
Streptavidin-HRP
Human IL-29 Standard lyophilized, 2ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

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Description

Description

IL-29 is a protein of the helical cytokine family and is a type III interferon sharing many functions with the type I family of interferons. The IL-29 gene is found on chromosome 19 in humans. It is also known as IFN-lambda1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 does not bind the IFN-alpha/beta receptor, but instead signals through a receptor composed of the IL-28R1 and IL-10R2 subunits. Initial characterizations of the receptor demonstrated that it has a ubiquitous tissue distribution and is expressed on most non-hematopoietic cells.

Generation of native IL-29 is achieved by monocytes and dendritic cells in response to viral infection and stimulation with toll-like receptor ligands. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL 29 has significant antiviral activity and immunoregulatory properties and appears to inhibit T helper-2 (Th2) responses regarding inhibition of IL-13 production, compared with IL-4 or IL-5. The antiviral activities of IL-29 include the upregulation of MHC Class I expression on the cell surface and the expression of PKR. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Specifications

Specifications

ELISA
IFNL1, Interleukin 29
Biotin
2.0 pg/mL
50μL
Human
Plasma, Serum, Supernatants
Human

For Research Use Only

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