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Human IL-33 (aa 112-270), Recombinant Protein, Invitrogen™ Non-distribution product as customer accommodation.

E. coli Recombinant Protein

$250.50 - $2960.00

Specifications

Recombinant Yes
Name Human IL-33 (aa 112-270)
For Use With (Application) Control, ELISA, Western Blot
Concentration 200 µg/mL
Conjugate Unlabeled
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Products 4
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIRP87832 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87832
10 µg
Each for $250.50
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PIRP87833 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87833
25 µg
Each for $443.00
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PIRP87834 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87834
100 µg
Each for $1,156.00
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PIRP87835 Non-distribution product as customer accommodation.
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Thermo Scientific
RP87835
500 µg
Each for $2,960.00
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Description

Description

IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer's patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties.
Specifications

Specifications

Yes
Control, ELISA, Western Blot
Unlabeled
PBS with 1 mM EDTA, 2 mM DTT and no preservative; pH 7.2
E. coli
-20°C
O95760
IL33
>95%
Human IL-33 (aa 112-270)
200 µg/mL
Liquid
9230117N10Rik; C9orf26; DVS27; DVS27-related protein; H-IL-33; Il1f11; IL-1F11; Il33; IL-33; ILN; Interleukin; interleukin 33; Interleukin-1 family member 11; Interleukin33; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33(102-266); Interleukin-33(109-266); NFEHEV; NFHEV; NF-HEV; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; RGD1311155; RP11-575C20.2
RUO
Human
90865
18 kD
SDS
Product Certifications
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