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Invitrogen™ MIP-1b (CCL4) Human Instant ELISA™ Kit Non-distribution product as customer accommodation.

For the quantitative detection of MIP-1beta levels in cell culture supernatants, serum and plasma.

Manufacturer:  Invitrogen™ BMS2030INST

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Catalog No. 50-179-19


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Includes: Aluminium pouch(es) with a Microwell Plate coated with Polyclonal Antibody to MIP-1beta, Biotin-Conjugate (anti-MIP-1beta polyclonal antibody), Streptavidin-HRP and Sample diluent, lyophilized
Aluminium pouch(es) with a human MIP-1beta Standard curve (coloured)
Wash Buffer Concentrate 20x (phosphate-buffered saline with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Sample Diluent (Use when an external predilution of the samples is needed)
Stop Solution (1M Phosphoric acid)
Adhesive Plate Covers

Description

Description

CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
Specifications

Specifications

P13236
Biotin
6351
ELISA Kit
3.0 pg/mL
Plasma, 50 μL|Serum, 50 μL|Supernatant, 50 μL
20 min.
Human
CCL4, LAG-1, Small inducible cytokine A4, SCYA4
7.2%
Human
HRP
7.8-500 pg/mL
ELISA
Adhesive Plate Covers
RUO
50 μL
-20°C
3 hr. 10 min.
ACT2,AT744.1,G-26,HC21,LAG-1,LAG1,MIP-1-beta,MIP1B,MIP1B1,SCYA2,SCYA4
4.9%
128 Tests
Plasma, Serum, Supernatant
Colorimetric Microplate Reader
SDS
Documents
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