Gibco™ Human Resistin Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Catalog Number	Mfr. No.	Quantity
45019100UG	Gibco™ 45019100UG	100 μg
450-19-1MG	Gibco™ 450191MG	1 mg
45019250UG	Gibco™ 45019250UG	250 μg
450-19-25UG	Gibco™ 4501925UG	25 μg
45019500UG	Gibco™ 45019500UG	500 μg
450-19-50UG	Gibco™ 4501950UG	50 μg
450-19-5UG	Gibco™ 450195UG	5 μg

Description

Adipose tissue is an energy reserve in animals and is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), perilipin, and resistin. Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine that is specifically secreted by adipocytes. While the function of resistin is not well understood, it appears to have key paracrine roles and has a suggested role in type 2 diabetes. Studies show that in obese, diabetic mice the levels of serum resistin are increased, which has an antagonistic effect on insulin. Additional studies have shown that resistin causes insulin resistance and glucose intolerance in mice. Resistin gene expression requires C/EBP alpha, which is necessary and sufficient for expression. Studies show that the coactivators CBP and p300, which have been shown to display histone acetyltransferase (HAT) activity, abundantly acetylate the histones at the resistin promoter suggesting their role in activating chromatin for resistin transcription. Numerous PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.

Specifications

• Accession Number: Q9HD89
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 19.5
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: Adipose tissue specific secretory factor; adipose tissue-specific secretory factor; Adipose-specific cysteine-rich secreted protein A12-alpha; ADSF; C/EBP epsilon regulated myeloid specific secreted cysteine rich protein precursor 1; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; cysteine-r; Cysteine-rich secreted protein A12-alpha-like 2; cysteine-rich secreted protein FIZZ3; dominant inhibitory adipocyte-specific secretory factor; dri; FIZZ3; found in inflammatory zone 3; HXCP1; MGC126603; MGC126609; Resistin; resistin delta2; RETN; RETN1; RSN; RSTN; UNQ407/PRO1199; XCP1; Xcp4
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Gene ID (Entrez): 56729
• Name: Human Resistin
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: RETN
• Conjugate: Unconjugated
• Sequence: SSKTLCSMEE AINERIQEVA GSLIFRAISS IGLECQSVTS RGDLATCPRG FAVTGCTCGS ACGSWDVRAE TTCHCQCAGM DWTGARCCRV QP
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.