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Invitrogen™ eBioscience™ Human sCD40 Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of human sCD40.

Manufacturer:  Invitrogen™ BMS265TEN

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Catalog No. 50-181-93


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human sCD40
Biotin-Conjugate anti-human sCD40 monoclonal antibody
Streptavidin-HRP
Human sCD40 Standard lyophilized, 1ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
Specifications

Specifications

P25942
Biotin
958
Adhesive Plate Covers
10 x 96 tests
1.3 pg/mL
50μL
Human
1 hr 20 min
Human
B-cell associated molecule CD40, Bp 50, CDw40
5.5%
7.8-500 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA
RUO
Amniotic Fluid, Plasma, Serum, Supernatants
Amniotic Fluid (50μL), Plasma (50μL), Serum (50μL), Supernatants (50μL)
2-8°C
3 hr 10 min
CD40
7%
HRP
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