Invitrogen eBioscience Human sE-selectin Platinum ELISA Kit
For the quantitative detection of human sE-selectin.
Manufacturer: Invitrogen BMS205
DescriptionE-selectin (CD62E, ELAM-1, and LECAM-1) is a 115 kD type I membrane protein and a member of the selectin family. E-selectin is highly expressed on activated endothelial cells (IL-2, TNF- alpha, other cytokines can increase expression) and can also be expressed on endothelial cells in the skin, bone marrow and placenta. E-selectin is involved in tethering and leucocyte rolling on activated endothelium at inflammatory sites and may also play a role in tumor metastasis and angiogenesis. E-selectin binds to both Siayl Lewis X (CD15s) and PSGL-1 (CD162). The HCD62E antibody has been shown to recognize human E-selectin and to be useful for flow cytometry. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
|Pre-coated 96 well plate, Adhesive Plate Covers, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Controls|
|1 hr 20 min|
|ELAM1, endothelial adhesion molecule 1, CD62E|
|Colorimetric Microplate Reader|
|Plasma, Serum, Supernatants|
|Plasma (20μL), Serum (20μL), Supernatants (20μL)|
|2 hr 10 min|
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