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Huntingtin Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA1004

Catalog No. PIPA1004


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Description

Description

Neoepitope antibodies distinguish smaller cleaved fragments or processed forms of proteins versus the intact full-length or precursor by using a designed peptide purification process to maximize immunoreactivity to a specific cleavage site. Human HTT caspase cleavage sites generate fragment-specific forms of the protein. Caspase-3/7 has been shown to generate cleavage sites at animo acids 513 and 552. Caspase-2 cleaves at amino acid 552 and caspase-6 at amino acid 586. Neo-specific antibody PA1-004 recognizes the 586 cleaved fragment without detecting the full-length form.

Huntingtin Polyclonal antibody specifically detects Huntingtin in Human, Mouse samples. It is validated for ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Huntingtin
Polyclonal
Unconjugated
Htt
AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Rabbit
Affinity chromatography
RUO
15194, 3064
-20°C
Liquid
ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
0.6 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P42858, P42859
Htt
Synthetic peptide conjugated to KLH via cysteine corresponding to CPSDSSEIVLD (577-586) of Human HTT.
100 μL
Primary
Human, Mouse
Antibody
IgG
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