HVEM/TNFRSF14 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 101381AP150UL

Catalog No. 50-172-6053

Description

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.

Specifications

• Antigen: HVEM/TNFRSF14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF14
• Gene Alias: ATAR, Herpes virus entry mediator A, Herpesvirus entry mediator A, HVEA, HVEM, LIGHTR, TNFRSF14, TR2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8764
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.27 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q92956
• Gene Symbols: TNFRSF14
• Immunogen: HVEM/TNFRSF14 Fusion Protein Ag0186
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid