Invitrogen™ HYAL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530283

Catalog No. PIPA530283

Description

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (88%), Rat (88%), Pig (93%), Sheep (91%), Rhesus Monkey (100%), Bovine (91%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

Specifications

• Antigen: HYAL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HYAL2
• Gene Alias: AI256841; AU020858; AW555733; HYAL2; Hyal-2; Hyaluronidase; hyaluronidase 2; hyaluronidase-2; hyaluronoglucosaminidase 2; hyaluronoglucosaminidase-2; LUCA2; LuCa-2; lung carcinoma protein 2; lysosomal hyaluronidase; PH20 homolog; PH-20 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15587, 8692
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O35632, Q12891
• Gene Symbols: HYAL2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 127 and 375 of Human HYAL2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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