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IkB zeta Rat anti-Mouse, Clone: LK2NAP, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  Invitrogen 14680182

Catalog No. 50-112-2720


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Description

Description

Description: The LK2NAP monoclonal antibody reacts with mouse IkB zeta (INAP, MAIL). IkBz is a member of the IkB family of cytoplasmic proteins and transcription factors and also shares structural homology with Bcl-3. It is induced in monocytes, macrophages and B cells in response to TLR and IL-1R signaling. In NK cells, IkBz is rapidly upregulated in response to IL-12 and IL-18 and is necessary for production of IFN gamma. In T cells, IkBz is not necessary for IFN gamma and IL-4 production by Th1 and Th2 cells, respectively. However in Th17 cells, IkBz acts in concert with RORa and RORgt to upregulate IL-17A, IL-17F, IL-21, IL-22 and IL-23R expression. Applications Reported: This LK2NAP antibody has been reported for use in western blotting. Applications Tested: This LK2NAP antibody has been tested by western blotting on reduced lysates at > 1 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.

I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombit IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
Specifications

Specifications

IkB zeta
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9EST8
FLJ30225, FLJ34463, IKBZ, INAP, MAIL
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Western Blot
LK2NAP
Unconjugated
Nfkbiz
Liquid
Nfkbiz
IgG2a, kappa
100 μg
4° C
Primary
80859
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