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IA-1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA5107148

Catalog No. PIPA5107148


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Description

Description

Sequence homology: Cow: 86%; Dog: 92%; Horse: 85%; Human: 100%; Pig: 92%

IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
Specifications

Specifications

IA-1
Polyclonal
Unconjugated
INSM1
Liquid
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
3642
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Q01101
INSM1
Synthetic peptide located within the following region: LQAKGAPLAP PAEDLLALYP GPDEKAPQEA AGDGEGAGVL GLSASAECHL
Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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