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PTPRN Rabbit anti-Human, Polyclonal, Invitrogen

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA564913

Catalog No. PIPA564913


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Description

Description

Immunogen sequence: HSYGDLPGPSP AQLFQDSGLL YLAQELPAPS RARVPRLPEQ GSSSRAEDSP EGYEKEGLGD RGEKPASPAV QPDAALQRLA AVLAGYGVEL RQLTPEQLST LLTLLQLLPK GA Highest antigen sequence identity to the following orthologs - mouse 77%, rat 81%.

IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids in length and consists of a luminal domain, transmembrane domain, and cytoplasmic domain. Although a member of the PTP family, IA-2 lacks phosphatase activity with known substrates due to amino acid substitutions at critical sites in its PTP domain. Two paralog RPTPs, IA-2 and IA-2beta were identified as major autoantigens in type-1 diabetes mellitus. On granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting cytosolic fragment moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis. IA-2 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
Specifications

Specifications

PTPRN
Polyclonal
Unconjugated
PTPRN
Liquid
PTPRN
Recombit Human PTPRN
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence
0.05 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q16849
IA-2; protein tyrosine phosphatase; receptor type N; FLJ16131; IA-2/PTP; IA2; ICA512; R-PTP-N; islet antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
5798
SDS
Documents
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