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ICA 121431, Tocris Bioscience™

Catalog Number 506610
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Quantity:
10 mg
50 mg
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313254-51-2
C23H19N3O3S2
449.543
URSQNPPONHUJDL-UHFFFAOYSA-N
2,2-diphenyl-n-4-n-thiazol-2-yl sulfamoyl phenyl acetamide, 2,2-diphenyl-n-4-1,3-thiazol-2-ylsulfamoyl phenyl acetamide, 2,2-diphenyl-n-4-thiazol-2-ylsulfamoyl-phenyl-acetamide, 2,2-diphenyl-n-4-1,3-thiazol-2-yl sulfamoyl phenyl acetamide, 2,2-diphenyl-n-4-1,3-thiazol-2-ylamino sulfonyl phenyl acetamide, alpha-phenyl-n-4-2-thiazolylamino sulfonyl phenyl-benzeneacetamide
998021
2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4
missing translation for 'nonReturnableMessage' missing translation for 'returnPolicyLabel'
313254-51-2
C23H19N3O3S2
449.543
URSQNPPONHUJDL-UHFFFAOYSA-N
2,2-diphenyl-n-4-n-thiazol-2-yl sulfamoyl phenyl acetamide, 2,2-diphenyl-n-4-1,3-thiazol-2-ylsulfamoyl phenyl acetamide, 2,2-diphenyl-n-4-thiazol-2-ylsulfamoyl-phenyl-acetamide, 2,2-diphenyl-n-4-1,3-thiazol-2-yl sulfamoyl phenyl acetamide, 2,2-diphenyl-n-4-1,3-thiazol-2-ylamino sulfonyl phenyl acetamide, alpha-phenyl-n-4-2-thiazolylamino sulfonyl phenyl-benzeneacetamide
998021
2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4

Description

Potent and selective NaV1.3 and NaV1.1 channel blocker

Potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.
Color White
Quantity 10 mg
Formula Weight 449.55
Percent Purity >98%
Physical Form Solid
Chemical Name or Material ICA 121431

Safety and Handling

Recommended Storage Store at +4°C
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