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Mouse ICAD, Synthetic Peptide, Invitrogen™

Synthetic Peptide

Manufacturer:  Invitrogen PEP0017

Catalog No. PEP0017


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Description

Description

ICAD Synthetic Peptide, PEP-0017, from Invitrogen.

ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD. In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone. There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene. This peptide corresponds to 20 amino amino terminus of mouse ICAD.PEP-0017 can be used as a blocking peptide with polyclonal antibody PA5-19889.
Specifications

Specifications

Synthetic Peptide
purified
50μg
Blocking Assay, Control
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Mouse
RUO
0.02% sodium azide
Dffa
Blocking Assay, Control
13347
Mouse
200μg/mL
Liquid
N
PBS
-20°C
Mouse ICAD
O54786
Peptide
Documents
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