ICAM-4 Sheep anti-Human, PE, Polyclonal, R&D Systems
Sheep Polyclonal Antibody
Manufacturer: R&D Systems FAB7179P025
DescriptionICAM-4 (Intercellular Adhesion Molecule 4), also known as Landsteiner-Wiener glycoprotein and CD242, is a 42kDa member of the ICAM family, Ig superfamily of proteins. It is expressed on erythrocytes and erythroblasts, and serves as a receptor for LFA-1, Mac-1, and CD11c/CD18, plus α4β1 and alpha-V containing integrins. ICAM-4 is suggested to bind to Mac-1 on macrophages, allowing for its phagocytosis in senescence. Mature human ICAM-4 is a 249 amino acid (aa) type I transmembrane glycoprotein. It possesses a 218 aa extracellular region (aa 23-240) that contains two C2-type Ig-like domains (aa 62-124 and 146-217), and a 10 aa C-terminal cytoplasmic tail. ICAM-4 may form 85kDa homodimers. There are three potential isoform variants. One shows a five aa substitution for aa 233-271, a second contains a 15 aa substitution for aa 14-29, and a third possesses a 141 aa substitution for aa 132-271. Over aa 31-240, human ICAM-4 shares 71% aa sequence identity with mouse ICAM-4.
|Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide|
|Chinese hamster ovary cell line CHO-derived recombinant human ICAM-4, Ala31-Ala240, Accession # Q14773|
|Flow Cytometry 10 uL/10^6 cells|
|CD242, CD242 antigen, ICAM4, ICAM-4, intercellular adhesion molecule 4, intercellular adhesion molecule 4 (Landsteiner-Wiener blood group), intercellular adhesion molecule 4 (LW blood group), intercellular adhesion molecule 4, Landsteiner-Wiener blood group, Landsteiner-Wiener blood group, Landsteiner-Wiener blood group antigen a, Landsteiner-Wiener blood group glycoprotein, LWLW blood group protein|
|Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.|
|Detects human ICAM-4 in direct ELISAs and Western blots.|
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