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ICAM-4 Sheep anti-Human, PE, Polyclonal, R&D Systems™

Sheep Polyclonal Antibody

$169.00 - $329.00

Specifications

Antigen ICAM-4
Formulation Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
Format Affinity Purified
Applications Flow Cytometry
Conjugate R-PE
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
FAB7179P025 View Documents R&D Systems
FAB7179P025
25 Tests Each for $169.00
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FAB7179P100 View Documents R&D Systems
FAB7179P100
100 Tests Each for $329.00
Add to cart
 
Description

Description

ICAM-4 (Intercellular Adhesion Molecule 4), also known as Landsteiner-Wiener glycoprotein and CD242, is a 42kDa member of the ICAM family, Ig superfamily of proteins. It is expressed on erythrocytes and erythroblasts, and serves as a receptor for LFA-1, Mac-1, and CD11c/CD18, plus α4β1 and alpha-V containing integrins. ICAM-4 is suggested to bind to Mac-1 on macrophages, allowing for its phagocytosis in senescence. Mature human ICAM-4 is a 249 amino acid (aa) type I transmembrane glycoprotein. It possesses a 218 aa extracellular region (aa 23-240) that contains two C2-type Ig-like domains (aa 62-124 and 146-217), and a 10 aa C-terminal cytoplasmic tail. ICAM-4 may form 85kDa homodimers. There are three potential isoform variants. One shows a five aa substitution for aa 233-271, a second contains a 15 aa substitution for aa 14-29, and a third possesses a 141 aa substitution for aa 132-271. Over aa 31-240, human ICAM-4 shares 71% aa sequence identity with mouse ICAM-4.
Specifications

Specifications

ICAM-4
Affinity Purified
R-PE
IgG
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.
Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
Flow Cytometry
Sheep
Antigen Affinity-purified
RUO
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