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ID3 Mouse anti-Human, Clone: OTI15E3, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA500757

Catalog No. 50-167-1898


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Description

Description

Members of the Id family of basic helix-loop-helix (bHLH) proteins include ID1, ID2, ID3 and ID4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The ID-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since ID1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the ID protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the ID proteins is strongly dependent on growth factor activation and that reduction of ID mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.
Specifications

Specifications

ID3
Monoclonal
0.64 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q02535
HEIR-1, bHLHb25
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3399
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI15E3
Unconjugated
ID3
Liquid
ID3
Full length human recombit protein of human ID3 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
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